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Post by Home Grown Poultry » Fri Mar 18, 2016 2:39 pm

Im sorry for fear mongering guys. but I dont feel theres any problem with taking any and all safe guards to protect oneself and their family. clearly its still not fully understood and aluminum is still a part of the problem. Kathy I hope your research figures it all out one day and is published immediately so we can all know for a fact. not years later.

I also hope that one day pharmaceutical company's, ect start caring about people more than money.

from this point on I am not engaging in controversial subjects on the board. you will have to catch me around a campfire. :-)

and Man is not God.

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Post by SandyM » Fri Mar 18, 2016 2:42 pm

SandyM wrote:QR_BBPOST Epigenetic modifications can manifest as commonly as the manner in which cells terminally differentiate to end up as skin cells, liver cells, brain cells,
What does this mean? Terminally being permanent?
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Post by SandyM » Fri Mar 18, 2016 2:45 pm

thegawd wrote:QR_BBPOST Im sorry for fear mongering guys. but I dont feel theres any problem with taking any and all safe guards to protect oneself and their family. clearly its still not fully understood and aluminum is still a part of the problem. Kathy I hope your research figures it all out one day and is published immediately so we can all know for a fact. not years later.
thegawd wrote:QR_BBPOST you will have to catch me around a campfire.
I also hope that one day pharmaceutical company's, ect start caring about people more than money.

from this point on I am not engaging in controversial subjects on the board. you will have to catch me around a campfire. :-)

and Man is not God.

:beer:
might be worth the drive to Lambton is it?
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Post by WLLady » Fri Mar 18, 2016 2:50 pm

Sorry al....i really didnt want to sound harsh....please dont stop engaging.

So theres another side to epigenetics which is the methylation of grandmas genes affecting granddaughter...its a reversible change but we dont know how to reverse it in people. Generally once a cell is say a liver cell it is a liver cell until it dies. Thats called termnal differentiation. It doesnt become another cell after being a liver cell. However something like a musce satellite cell is not terminally differentiated-it is partly there. It has gone from a stem cell to a satellite cell-so technically differentiated but not terminally. It cannot normally become a stem cell again but can further differentiate into a new muscle cell. Happens all the time when muscles are damaged though work.

Okay. Al, one again i am very sorry. I will go....please dont stop posting the theories...25 years ago it was a theory that aluminum causes alzheimers...its just turned out it isnt....and that never seemed to get reported while the previous was. Selective reporting.
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Post by SandyM » Fri Mar 18, 2016 2:55 pm

Theories are relevant and interesting. Before something is anything, it's usually someone's theory.

Ok, that makes sense Kathy. Sort of. A little bit. Maybe. I get my liver cells don't retire and head over to my muscle, because they're an organ cell(s)? But we have floaters that are essentially waiting for a need or a job? That's cool!
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Post by Home Grown Poultry » Fri Mar 18, 2016 3:00 pm

i stopped researching all this stuff years ago... so no worries. there is a lot of conflicting scientific papers on the subject. and I am definitely fact driven. most of what I read today is a few years old at best and they cant say how much of a factor it is... I would love to read brand new data. they all pretty much summerize up into there is no significant evidence that aluminum causes it but like you said aluminum is present in the victims, but not always.

no worries...

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Post by WLLady » Fri Mar 18, 2016 3:11 pm

Standing joke here is if there was one study we wished we had never doneit was the rabbit study lol
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Post by WLLady » Fri Mar 18, 2016 3:15 pm

And therein lies the issue al.....the papers etc publish all the new OMG stuff and never the oh...wait....stuff. because at least in journalism it wouldnt sell half as well. I will see if i can find a half decent review article from one of the journals for you....
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Post by WLLady » Fri Mar 18, 2016 3:27 pm

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts.Review article

Willhite CC, et al. Crit Rev Toxicol. 2014.

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Abstract

Abstract Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); it is also present in ambient and occupational airborne particulates. Existing data underscore the importance of Al physical and chemical forms in relation to its uptake, accumulation, and systemic bioavailability. The present review represents a systematic examination of the peer-reviewed literature on the adverse health effects of Al materials published since a previous critical evaluation compiled by Krewski et al. (2007) . Challenges encountered in carrying out the present review reflected the experimental use of different physical and chemical Al forms, different routes of administration, and different target organs in relation to the magnitude, frequency, and duration of exposure. Wide variations in diet can result in Al intakes that are often higher than the World Health Organization provisional tolerable weekly intake (PTWI), which is based on studies with Al citrate. Comparing daily dietary Al exposures on the basis of "total Al"assumes that gastrointestinal bioavailability for all dietary Al forms is equivalent to that for Al citrate, an approach that requires validation. Current occupational exposure limits (OELs) for identical Al substances vary as much as 15-fold. The toxicity of different Al forms depends in large measure on their physical behavior and relative solubility in water. The toxicity of soluble Al forms depends upon the delivered dose of Al(+3) to target tissues. Trivalent Al reacts with water to produce bidentate superoxide coordination spheres [Al(O2)(H2O4)(+2) and Al(H2O)6 (+3)] that after complexation with O2(•-), generate Al superoxides [Al(O2(•))](H2O5)](+2). Semireduced AlO2(•) radicals deplete mitochondrial Fe and promote generation of H2O2, O2 (•-) and OH(•). Thus, it is the Al(+3)-induced formation of oxygen radicals that accounts for the oxidative damage that leads to intrinsic apoptosis. In contrast, the toxicity of the insoluble Al oxides depends primarily on their behavior as particulates. Aluminum has been held responsible for human morbidity and mortality, but there is no consistent and convincing evidence to associate the Al found in food and drinking water at the doses and chemical forms presently consumed by people living in North America and Western Europe with increased risk for Alzheimer's disease (AD). Neither is there clear evidence to show use of Al-containing underarm antiperspirants or cosmetics increases the risk of AD or breast cancer. Metallic Al, its oxides, and common Al salts have not been shown to be either genotoxic or carcinogenic. Aluminum exposures during neonatal and pediatric parenteral nutrition (PN) can impair bone mineralization and delay neurological development. Adverse effects to vaccines with Al adjuvants have occurred; however, recent controlled trials found that the immunologic response to certain vaccines with Al adjuvants was no greater, and in some cases less than, that after identical vaccination without Al adjuvants. The scientific literature on the adverse health effects of Al is extensive. Health risk assessments for Al must take into account individual co-factors (e.g., age, renal function, diet, gastric pH). Conclusions from the current review point to the need for refinement of the PTWI, reduction of Al contamination in PN solutions, justification for routine addition of Al to vaccines, and harmonization of OELs for Al substances.

PMID 25233067 [PubMed - indexed for MEDLINE]

The full article is too big to copy and paste....but this one is from 2014....this is the summary of the paper. Notice how they keep saying that one has to look at everything-cofactors, age, pH, type of aluminum ion etc etc.

I think one thing that doesnt help is that the animal models - we can cause AD in mice and rabbits using the aluminum injections in these rodents. But remember rodents arent people....otherwise we would have cured sod1 associated ALS eons ago....we can cure those mice no problem. Doesnt work in people. Okay....DONE now. Lol
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Post by ross » Fri Mar 18, 2016 3:35 pm

I'm gone fishing too , to one sided for me , thanks Kathy good info , Luck
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ENJOY YOUR HUNTING / FISHING HERITAGE & the GREATNESS of CANADA

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